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  • 產(chǎn)品名稱： DM1
  • 產(chǎn)品貨號(hào)： CS00037
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 920
  • 數(shù)量：
    庫(kù)存： 10
  • 規(guī)格： 10mg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    產(chǎn)品描述
    Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
    靶點(diǎn)活性
    Others
    別名
    化合物Mertansine , Maytansinoid DM1 , DM1 
    純度
    98%
    分子量
     738.29 
    分子式
    C35H48ClN3O10S
    CAS No.
    139504-50-0
    存儲(chǔ)
    Powder: -20°C for 3 years
    In solvent: -80°C for 2 years
    溶解度
    H2O: < 0.1 mg/mL (insoluble)
    DMSO: 83.33 mg/mL (112.87 mM)
    ( < 1 mg/ml refers to the product slightly soluble or insoluble )
    參考文獻(xiàn)
    1. Whiteman KR, et al. MAbs. 2014 Mar-Apr;6(2): 556-66.
    2. Wang Y Q, Ji M Y, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy[J]. International Journal of Pharmaceutics. 2020: 119331.
    Note
    For research use only .