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  • 產(chǎn)品名稱： Recombinant Human pro-GRP Protein(C-10His)
  • 產(chǎn)品貨號： CS06035
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購： 2200
  • 數(shù)量：
    庫存： 5
  • 規(guī)格： 10ug
  • 產(chǎn)品信息
  • 如何訂購
    種屬
    Human
    來源
    HEK 293
    分子量
    Detects a band of approximately 13 kD(Predicted molecular weight: 9.4 kD)
    外觀
    Lyophilized Powder
    形態(tài)
    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
    序列
    Ser54-Asp121
    STGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDGGGGSHHHHHHHHHH
    標(biāo)簽
    C-10His
    純度
    ＞95% by SDS-PAGE
    內(nèi)毒素水平
    < 1EU/ug
    標(biāo)記
    unconjugated
    溶解方法
    Centrifuge tubes before opening.Reconstitute no more than 0.1 mg/mL according to the size in deionized water.
    儲存/保存方法
    Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -120 °C as supplied. Avoid repeated freeze-thaw cycles.
    背景說明
    Pro-Gastrin-Releasing-Peptide, also known as Pro-GRP, is a Gastrin-Releasing-Peptide (GRP) precursor, a neurotransmitter that belongs to the bombesine/neuromedin B family. GRP stimulates the secretion of gastrin in order to increase the acidity of the gastric acid. Pro-GRP is a peptide composed of 125 amino acids, expressed in the nervous system and digestive tract. In pathological situations, GRP has mitogenic activity in vitro in many tumors such as pancreatic, small cell lung (SCLC), prostate, kidney, breast and colorectal cancers. GRP could operate as an autocrine growth factor. In cancers, GRP induces cell growth and inhibits apoptosis by shutting down the endoplasmic reticulum stress pathway. As early as 1994, research on Pro-GRP as a biomarker for small cell lung cancer began. Because of the very short half-life of GRP (2 minutes), the Pro-GRP is used for measurements and analysis. Since then, Pro-GRP has been used as a tumor marker for patients with small cell lung cancer (SCLC) in limited and extended stages.
    Accession
    P07492
    實(shí)驗(yàn)結(jié)果圖
    icon
    Note
    For research use only.