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  • 產(chǎn)品名稱： Research Grade Natalizumab ( 那他珠單抗 )
  • 產(chǎn)品貨號： CSD00020
  • 貨期： 現(xiàn)貨
  • 價格與訂購： 2480
  • 數(shù)量：
    庫存： 100
  • 規(guī)格： 100μg
  • 產(chǎn)品信息
  • 如何訂購
    貨號（Catalog No.）
    CSD00020
    通用名INN
    Natalizumab
    純度(Purity)
    >95%
    濃度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    內(nèi)毒素(Endotoxin level)
    Please contact with the lab for this information.
    產(chǎn)品描述(Description)
    Natalizumab is a recombinant, humanized monoclonal antibody,binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1).Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.
    別名(Alternative names)
    AN 100226,BG00002
    靶點;物種(Specificity target name;species)
    ITGA4/CD49d[Homo sapiens]
    活性研究（體外/體內(nèi)研究）(Activity in vitro)
    Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.
    種類(Species)
    Humanized
    受體鑒定(Receptor identification)
    IgG4-kappa
    CAS
    189261-10-7
    存儲條件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .