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  • 產(chǎn)品名稱： Research Grade Abciximab ( 阿昔單抗 )
  • 產(chǎn)品貨號(hào)： CSD00074
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 3280
  • 數(shù)量：
    庫(kù)存： 100
  • 規(guī)格： 100μg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    貨號(hào)（Catalog No.）
    CSD00074
    通用名INN
    Abciximab
    純度(Purity)
    >95%
    濃度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    內(nèi)毒素(Endotoxin level)
    Please contact with the lab for this information.
    產(chǎn)品描述(Description)
    Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen,von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.Abciximab binds to the intact platelet GPIIb/IIIa receptor,which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation.This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa.By binding to the vitronectin receptor (also known as the αvβ3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion.Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
    別名(Alternative names)
    c7E3
    靶點(diǎn);物種(Specificity target name;species)
    ITGA2B_ITGB3[Homo sapiens]
    種類(Species)
    Chimeric
    受體鑒定(Receptor identification)
    Fab-G1-kappa
    分子量(MV)
    145651.1 Da
    CAS
    143653-53-6
    存儲(chǔ)條件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .