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  • 產(chǎn)品名稱： Research Grade Ipilimumab ( 伊匹木單抗 )
  • 產(chǎn)品貨號： CSD00107
  • 貨期： 現(xiàn)貨
  • 價格與訂購： 3000
  • 數(shù)量：
    庫存： 10
  • 規(guī)格： 1mg
  • 產(chǎn)品信息
  • 如何訂購
    貨號（Catalog No.）
    CSD00107
    通用名INN
    Ipilimumab
    純度(Purity)
    >95%
    電泳圖（SDS-PAGE image）
    濃度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    內(nèi)毒素(Endotoxin level)
    Please contact with the lab for this information.
    產(chǎn)品描述(Description)
    Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that competes with the stimulatory CD28 for binding to B7 on antigen presenting cells.3 CTLA-4 and CD28 are both presented on the surface of T-cells.3 Ipilimumab is a human IgG1 that binds CTLA-4, preventing the inhibition of T-cell mediated immune responses to tumors.
    別名(Alternative names)
    BMS-734016,MDX-010,MDX-CTLA-4
    靶點;物種(Specificity target name;species)
    CTLA4/CD152[Homo sapiens]
    活性研究（體外/體內(nèi)研究）(Activity in vitro)
    Ipilimumab (anti-CTLA-4), is a fully humanized IgG1k monoclonal antibody produced by recombinant DNA technology in a CHO mammalian cell expression system, binding with high affinity to the extracellular domain of human (and Cynomolgus monkey) CTLA-4, and acting as an inhibitor of its complex functions. This essentially results in T-cell activation and proliferation, and in lymphocyte infiltration leading to tumor cell death. However, the enhancement of T effector cell function, combined with the inhibition of CD4+ Treg and CD8+ suppressive cell types, are considered essential for mediating the full therapeutic effects of ipilimumab. Ipilimumab can improve ATC proliferation, enhance the BiAb-mediated tumor-specific cytotoxicity, and increase cytokine synthesis, while it attenuates Treg activity as shown by decreased level of IL-10 secretion and reduced Treg population. Ipilimumab and nivolumab treatments could collaboratively enhance effector and memory T cell responses without inappropriately activating naive T cells.
    種類(Species)
    Homo sapiens
    受體鑒定(Receptor identification)
    IgG1-kappa
    分子量(MV)
    148000.00 Da
    CAS
    477202-00-9
    存儲條件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .